Slower G-protein-linked receptor systems, as seen in the dopaminergic system, work through second-messenger systems, such as cyclic adenosine (Drug information on adenosine) monophosphate (cAMP), and have a longer duration of action.
Inhibition of the production of platelet activating factor and of leukotriene B4 in activated neutrophils by nimesulide due to an elevation of intracellular cyclic adenosine monophosphate. Arzneimittelforschung. 45, 1110-1114. Vane, J.R., Bakhle, Y.S., Botting, R.M., 1998.
Neuroprotective efficacy of nimesulide against hippocampal neuronal damage following transient forebrain ischemia