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  • WordNet 3.6
    • n acanthosis an abnormal but benign thickening of the prickle-cell layer of the skin (as in psoriasis)
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Century Dictionary and Cyclopedia
    • n acanthosis A name applied to any disease affecting primarily the stratum spinosum (prickle-cells) of the epidermis.
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In literature:

Acanthosis Nigricans may be defined as a general pigmentation with papillary mole-like growths.
"Anomalies and Curiosities of Medicine" by George M. Gould