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kinase

Definitions

  • WordNet 3.6
    • n kinase an enzyme that catalyzes the conversion of a proenzyme to an active enzyme
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Century Dictionary and Cyclopedia
    • n kinase A ferment-like body which is capable of rendering physiologically active another ferment and thus produces chemical changes in a third body while in itself it is apparently inert. Enterokinase, which occurs in the intestinal juice, renders the pancreatic trypsin active and thus brings about the digestion of albumins. Kinases probably occur widely distributed both in the animal and the vegetable world.
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Usage


In news:

The anaplastic lymphoma kinase (ALK) fusion gene and its mutations are responsible for about 5% of all non-small cell lung cancers (NSCLC), especially in patients who have never smoked.
Kinase Inhibitors Market to Reach $11.6 Billion in US, $40.3 Billion Globally by 2016.
Kinase Moves the Audio.
With a sound that goes from minimal to a massive wall of horns and percussion, Kinase Moves the Audio doesn't follow the usual local band blueprint.
Perioperative Tyrosine Kinase Inhibitors for GIST: Standard.
Phosphorylation of the Tumor Suppressor Fat Is Regulated by Its Ligand Dachsous and the Kinase Discs Overgrown.
Phosphorylation of the Tumor Suppressor Fat Is Regulated by Its Ligand Dachsous and the Kinase Discs Overgrown .
Role of scaffolds in MAP kinase pathway specificity revealed by custom design of pathway-dedicated s.
Activated CDC42-associated tyrosine kinase (ACK1) contributes to the progression of prostate tumours and metastatic potential of numerous cancers, two new studies report.
Regorafenib, a kinase inhibitor, is marketed as Stivarga.
Iclusig acts by blocking mutations that develop with the current class of drugs, called tyrosine kinase inhibitors, made by pharmaceutical giants Novartis AG and Bristol-Myers Squibb Co.
But the diagnostic test, which checks to see if a patient's tumor carries a mutation in a gene coding for anaplastic lymphoma kinase, called ALK, is just $250.
The targeted therapies used to treat leukemias and lymphomas include monoclonal antibodies, tyrosine kinase inhibitors, histone deacetylase inhibitors, hypermethylation inhibitors, and proteasome inhibitors.
On June 27, 2012, NICE published guidance recommending erlotinib as an option for the treatment of EGFR tyrosine kinase (EGFR-TK) mutation -positive advanced or metastatic non-small-cell lung cancer (NSCLC).
Nov 7, 2012 — Xeljanz, a new rheumatoid arthritis drug, is the first one that works by blocking enzymes called janus kinases.
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In science:

For example, the phosphorylated protein in the first module is the kinase in the second module, and the phosphorylated protein in the second module is the kinase in the third module.
TinkerCell: Modular CAD Tool for Synthetic Biology
Liaw. mars and tousled-like kinase act in parallel to ensure chromosome fidelity in drosophila.
A Developmental Network Theory of Gynandromorphs, Sexual Dimorphism and Species Formation
When a protein can be phosphorylated by a kinase, we write the chemical state of the protein as X = (αp), where 1=α or 0, and p indicates that the chemical modification takes place on the phosphorylation site.
Stable stochastic dynamics in yeast cell cycle
When a protein is targeted not only by a kinase but also by a ubiquitin ligase, then the phosphorylation site is denoted by p and the ubiquitination site is denoted by u.
Stable stochastic dynamics in yeast cell cycle
Regulation of Cdc28 cyclin-dependent e of the yeast Saccharomyces cerevisiae. protein kinase activity during the cell cycl Microbiol.
Stable stochastic dynamics in yeast cell cycle
The eukaryotic cell cycle operates through the sequential activation and deactivation of cyclin dependent protein kinases (CDKs).
The p53-MDM2 network: from oscillations to apoptosis
The active cyclin-CDK complex phoshorylates key intracellular proteins which in turn initiate or control important cell cycle events. The kinase Wee1 suppresses the activity of the cyclin-CDK complex through inhibitory phosphorylation.
The p53-MDM2 network: from oscillations to apoptosis
Altogether, the term protein-tyrosine kinase activity has 7 ancestors.
Multiple tests of association with biological annotation metadata
The portion of the MF DAG for the GO term protein-tyrosine kinase activity is displayed in Figure 2 using the QuickGO browser.
Multiple tests of association with biological annotation metadata
Portion of the directed acyclic graph for the GO term protein-tyrosine kinase activity (GO:0004713), in the Molecular Function ontology.
Multiple tests of association with biological annotation metadata
GOID = GO:0004713 Term = protein-tyrosine kinase activity Synonym = protein tyrosine kinase activity Definition = Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
Multiple tests of association with biological annotation metadata
Term = protein kinase activity Definition = Catalysis of the transfer of a phosphate group, usually from ATP, to a protein substrate.
Multiple tests of association with biological annotation metadata
As already noted in Example 2 and Figure 2, the term corresponding to the GO term ID GO:0004713 is protein-tyrosine kinase activity, in the Molecular Function ontology.
Multiple tests of association with biological annotation metadata
It has one (immediate) parent term, protein kinase activity.
Multiple tests of association with biological annotation metadata
GO[]$GOID, env=GOTERM) GOID = GO:0004713 Term = protein-tyrosine kinase activity Synonym = protein tyrosine kinase activity Definition = Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
Multiple tests of association with biological annotation metadata
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