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Tyrosin

Definitions

  • Webster's Revised Unabridged Dictionary
    • n Tyrosin (Physiol. Chem) A white crystalline nitrogenous substance present in small amount in the pancreas and spleen, and formed in large quantity from the decomposition of proteid matter by various means, -- as by pancreatic digestion, by putrefaction as of cheese, by the action of boiling acids, etc. Chemically, it consists of oxyphenol and amidopropionic acid, and by decomposition yields oxybenzoic acid, or some other benzol derivative.
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Century Dictionary and Cyclopedia
    • n tyrosin Tyrosin is p-oxyphenyl-propionic acid, —C6H4(OH).CH2.CH(NH2)COOH. It is obtained from nearly all albumins on hydrolytic decomposition by means of acids, alkalis, and the proteolytic ferments. It is supposed that a tyrosin radical exists as such in all those substances from which it is obtainable on decomposition.
    • n tyrosin A white crystalline body, odorless, and insoluble in cold water, having the formula C9H11NO3. It is an amido-acid, and forms salts with both acids and bases. It is a product of the decomposition of proteids, either by the ferment trypsin, by putrefaction, or by boiling with acids.
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Etymology

Webster's Revised Unabridged Dictionary
Gr. cheese

Usage

In literature:

Red colour = tyrosine.
"The Elements of Bacteriological Technique" by John William Henry Eyre
It is also found in horse's liver, being one of the putrefaction products of tyrosine.
"Encyclopaedia Britannica, 11th Edition, Volume 7, Slice 6" by Various
It is caused by the action of nitric acid on tyrosine.
"The Chemistry of Plant Life" by Roscoe Wilfred Thatcher
Bile-acids have been detected (Carter and Schmidt), and also leucin and tyrosin (Pribram and Robitschek).
"A System of Practical Medicine by American Authors, Vol. I" by Various
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In news:

The second generation tyrosine kinase inhibitor nilotinib (Drug information on nilotinib Tasigna) has proven to be an effective treatment for imatinib (Drug information on imatinib) -resistant patients with chronic myeloid leukemia (CML).
Crizotinib is a receptor tyrosine kinase inhibitor that blocks cell signaling by tyrosine kinases ALK, hepatocyte growth factor receptor (HGFR, c-Met) and Recepteur d'Origine Nantais (RON).
Tyrosine kinase inhibitors (TKIs) are indicated for the treatment of a variety of malignancies due to their ability to interfere with cell communication and growth.
Perioperative Tyrosine Kinase Inhibitors for GIST: Standard.
Itch is a common side-effect of treatment with anti-EGFR antibodies and tyrosine-kinase inhibitors.
FAK Phosphorylation by ERK Primes Ras -Induced Tyrosine Depho.
FAK Phosphorylation by ERK Primes Ras -Induced Tyrosine Dephosphorylation of FAK Mediated by PIN1 and.
Tyrosine is an amino acid, a building block of protein.
" Tyrosine is processed in the body from phenylalanine—another amino acid," explains Barbie Broschart, RD and a nutritional counselor.
Tyrosine kinase inhibitors (TKIs) are indicated for the treatment of a variety of malignancies due to their ability to interfere with cell communication and growth.
Activated CDC42-associated tyrosine kinase (ACK1) contributes to the progression of prostate tumours and metastatic potential of numerous cancers, two new studies report.
The ABL tyrosine kinase inhibitor STI571 is a promising agent for treatment of advanced Philadelphia-chromosome-positive (Ph+) acute lymphoblastic leukaemia.
Iclusig acts by blocking mutations that develop with the current class of drugs, called tyrosine kinase inhibitors, made by pharmaceutical giants Novartis AG and Bristol-Myers Squibb Co.
The targeted therapies used to treat leukemias and lymphomas include monoclonal antibodies, tyrosine kinase inhibitors, histone deacetylase inhibitors, hypermethylation inhibitors, and proteasome inhibitors.
On June 27, 2012, NICE published guidance recommending erlotinib as an option for the treatment of EGFR tyrosine kinase (EGFR-TK) mutation -positive advanced or metastatic non-small-cell lung cancer (NSCLC).
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In science:

Non-covalent interactions in proteins: (a) Evaluation of the strength of non-covalent interaction as in Ref 11. The interaction between the two residues Phenylalanine 33 (i) and Tyrosine 268(j) in L-arabinose binding protein (Pdb code: 8ABP) is shown, in which the residues i and j are separated in sequence ((i-j)>2).
Random Network Behaviour of Protein Structures
Asparagine, Cysteine, Glutamine, Glycine, Serine, Threonine, Tyrosine.
Protein folding and heteropolymers
Begovich, et al., A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis.
Genotype-based Case-Control Analysis, Violation of Hardy-Weinberg Equilibrium, and Phase Diagrams
It happens that 23 Da is also the mass difference between Tryptophan and Tyrosine, and if the candidate peptide contains a Tyrosine, RAId DbS will replace that Tyrosine with a Tryptophan and score the new peptide.
RAId DbS: A Mass-Spectrometry Based Peptide Identification Web Server with Knowledge Integration
Click on the small tree-like icon (top-left corner of the table) to display the tree view with all ancestors (i.e., less specific terms) of the GO term protein-tyrosine kinase activity.
Multiple tests of association with biological annotation metadata
Additional information may be obtained by clicking on the hyperlinked text protein-tyrosine kinase activity.
Multiple tests of association with biological annotation metadata
The GO term protein-tyrosine kinase activity has one (immediate) parent, protein kinase activity (GO:0004672), which itself has two parents, kinase activity (GO:0016301) and phosphotransferase activity, alcohol group as acceptor (GO:0016773).
Multiple tests of association with biological annotation metadata
Altogether, the term protein-tyrosine kinase activity has 7 ancestors.
Multiple tests of association with biological annotation metadata
The portion of the MF DAG for the GO term protein-tyrosine kinase activity is displayed in Figure 2 using the QuickGO browser.
Multiple tests of association with biological annotation metadata
Portion of the directed acyclic graph for the GO term protein-tyrosine kinase activity (GO:0004713), in the Molecular Function ontology.
Multiple tests of association with biological annotation metadata
GOID = GO:0004713 Term = protein-tyrosine kinase activity Synonym = protein tyrosine kinase activity Definition = Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
Multiple tests of association with biological annotation metadata
As already noted in Example 2 and Figure 2, the term corresponding to the GO term ID GO:0004713 is protein-tyrosine kinase activity, in the Molecular Function ontology.
Multiple tests of association with biological annotation metadata
GO[]$GOID, env=GOTERM) GOID = GO:0004713 Term = protein-tyrosine kinase activity Synonym = protein tyrosine kinase activity Definition = Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
Multiple tests of association with biological annotation metadata
In the following example, 205 distinct Affymetrix probe IDs are associated directly with the GO term protein-tyrosine kinase activity (GO:0004713).
Multiple tests of association with biological annotation metadata
In the following example, 319 distinct Affymetrix probe IDs (some with multiple evidence codes) are associated either directly or indirectly with the GO term protein-tyrosine kinase activity (GO:0004713).
Multiple tests of association with biological annotation metadata
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